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Set your HTML5 playback to 720p, 1080p, 4K or 2160p through your web browser. DOWNLOAD HD-Online-Player. Your browser will automatically play in HD. Click Here to Download a free test version of HD-Online-Player. Download the HD-Online-Player from the following location.Relation of genetic polymorphisms in CYP2D6 and ABCB1 to antiarrhythmic drug efficacy. Antiarrhythmic drug efficacy is known to be influenced by both genetic and non-genetic factors, including ethnicity. Pharmacogenetic factors have been studied previously in patients with the long QT syndrome (LQTS), and other genetic causes of LQTS, but have not been studied in other cardiac conditions, including the arrhythmic substrates of heart failure, atrial fibrillation, and ventricular tachycardia. We therefore investigated the relationship between drug efficacy in patients with these disorders and specific genetic polymorphisms in the major genes involved in the pharmacokinetics and pharmacodynamics of the antiarrhythmic drugs used in these conditions. From February 2001 to March 2005, a total of 327 patients with the various substrates of heart failure, atrial fibrillation, or ventricular tachycardia were given standard antiarrhythmic medications. All patients were enrolled in a prospective, placebo-controlled, double-blinded pharmacogenetic study using drug (Sotalol or Amiodarone) and placebo. Drug-induced change in rate-corrected QT interval (QTc), conduction intervals, and arrhythmic events were used to assess drug efficacy. Pharmacokinetic data were obtained from all patients enrolled, and gene polymorphisms in CYP2D6 (CYP2D6*10 and CYP2D6*5) and ABCB1 (1236 C>T, 2677 G>T/A, and 3435 C>T) were genotyped by PCR. There was a statistically significant (P T polymorphism, with 3435 T allele carriers having higher efficacy. There was also a trend (P = 0.08) for drug efficacy to be higher in patients with the 2677 T allele. No other correlation was found between antiarrhythmic efficacy and polymorphisms in the CYP2D6 gene. Our results suggest that ABCB1 genotypes may be




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HD Online Player (License Key Atlas Ti 7) clewate

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